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echinacea purpurea extract (whole plant)
extract of the whole plant of the coneflower, echinacea purpurea (l.), asteraceae

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CAS Number: 90028-20-9
ECHA EC Number:289-808-4
Category:cosmetic agents, dietary supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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Physical Properties:
Food Chemicals Codex Listed: No
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: moisturising agents
skin conditioning
tonic
 
Suppliers:
Amax Nutrasource
Echinacea Purpurea Herb Extract, 4% Phenols
AuNutra® Industries
Echinacea Purpurea P.E.
Bell Flavors & Fragrances
Echinacea Extract Natural
Carrubba
echinacea extract
Dongguan Meiherb Biotech
Echinacea Purpurea Extract
Odor: characteristic
Use: Echinacea extract is the most widely medicinal plant and is commonly used for cold, toothache, snake bites and other trauma. The United States has used it for many years as an alternative medicine to enhance the immune system and clear blood, especially in time of seasonal changes and frequent episodes of cold and cough.
Jiangyin Healthway
Echinacea Purpurea P.E.
New functional food ingredients
Lipotec USA
Actiphyte® of Coneflower Extract
Naturex
Echinacea Purpurea Extract
NAT healthy™
Omega Ingredients
Echinacea kiiNote®
OQEMA
Echinacea Extract
Qingdao Dacon Trading
Echinacea Purpurea Extract
Shaanxi Haokang Bio-technology
Echinacea Extract (Phenolics 4.0%)
Echinacea Extract, Natural
Symrise
Actipone® Echinacea GW
Odor: characteristic
Use: Actipone® Echinacea GW contains the extract of Echinacea purpurea L. plants prepared in a mixture of water and glycerin. Echinacea used for our Actipone® is mainly cultivated in Spain and Germany. The fresh plants are cut while flowering, the herb is pressed, extracted with water and alcohol, and filtrated. The filtrate is concentrated by distillation and thereby the ethanol is completely removed. The concentrated extract is prepared in a mixture of water, glycerin and preservatives and clear filtrated after an individual ripening time. 1kg Actipone® Echinacea GW contains the hydrophilic ingredients of approx. 1.25 kg fresh echinacea herbs. Fresh Plant Material - Actipone® Echinacea GW ? Ratio: 1.25 : 1 Actipone® Echinacea GW shows anti-aging (sirtuin enhancing), anti-irritant and anti-oxidant properties (in vitro).
Symrise
SymFinity® 1298
Odor: characteristic
Use: 100% natural echinacea purpurea extract with proven "3-in-1" anti-aging benefits: activates sirtuin, works as skin soother and has antioxidant properties. Convincing results of in vivo anti-aging study (tested at 0.1%): ? up to 12% smoother skin ? up to 12% reduction of fine lines and wrinkles. SymFinity® 1298 has an excellent anti-irritant activity comparable to bisabolol (inhibits IL-1a, COX-2 & PGE2) and therefore makes it the perfect ingredient for stressed and sensitive skin. SymFinity® 1298 is also an effective hyaluronic acid stimulator.
Vege Tech
Organic Echinacea Extract
Vigon International
Symfinity 1298
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
cosmetic agents, dietary supplements
Recommendation for echinacea purpurea extract (whole plant) usage levels up to:
 not for fragrance use.
 
Recommendation for echinacea purpurea extract (whole plant) flavor usage levels up to:
 not for flavor use.
 
Safety References:
ClinicalTrials.gov:search
Daily Med:search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:2
echinacea purpurea extract
Chemidplus:0090028209
 
References:
 echinacea purpurea extract
Pubchem (sid):135352378
 
Other Information:
FDA Listing of Food Additive Status:View
Wikipedia:View
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 echinacea purpurea
Search Trop Picture
 
Synonyms:
 coneflower extract
 echinacea extract
actipone echinacea GW (Symrise)
 echinacea kiinote (Omega)
 extract of the whole plant of the coneflower, echinacea purpurea (l.), asteraceae
 symfinity 1298 (Symrise)
 

Articles:

PubMed:Effects of cichoric acid extract from Echinacea purpurea on collagen-induced arthritis in rats.
PubMed:Immune enhancing effects of Echinacea purpurea root extract by reducing regulatory T cell number and function.
PubMed:Effects of Echinacea purpurea on Hepatic and Renal Toxicity Induced by Diethylnitrosamine in Rats.
PubMed:Echinacea purpurea (L.) Moench modulates human T-cell cytokine response.
PubMed:In vivo screening of four phytochemicals/extracts and a fungal immunomodulatory protein against an Eimeria acervulina infection in broilers.
PubMed:Echinacea purpurea root extract enhances the adipocyte differentiation of 3T3-L1 cells.
PubMed:The effect of Echinacea purpurea on the pharmacokinetics of docetaxel.
PubMed:Lactic acid fermentation as a tool to enhance the functional features of Echinacea spp.
PubMed:In vivo screening of five phytochemicals/extracts and a fungal immunomodulatory protein against colibacillosis in broilers.
PubMed:Anti-inflammatory effects of essential oil in Echinacea purpurea L.
PubMed:Efficacy and safety of Echinaforce? in respiratory tract infections.
PubMed:Safety and Efficacy Profile of Echinacea purpurea to Prevent Common Cold Episodes: A Randomized, Double-Blind, Placebo-Controlled Trial.
PubMed:In vitro inhibition of Eimeria tenella invasion of epithelial cells by phytochemicals.
PubMed:Cytotoxic effects of Echinacea purpurea flower extracts and cichoric acid on human colon cancer cells through induction of apoptosis.
PubMed:Treatment of the common cold in children and adults.
PubMed:Herb-drug interaction between Echinacea purpurea and etravirine in HIV-infected patients.
PubMed:The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS.
PubMed:Determination of major phenolic compounds in Echinacea spp. raw materials and finished products by high-performance liquid chromatography with ultraviolet detection: single-laboratory validation matrix extension.
PubMed:Neuroprotective effects of a new skin care formulation following ultraviolet exposure.
PubMed:Applications of the phytomedicine Echinacea purpurea (Purple Coneflower) in infectious diseases.
PubMed:Evaluating the efficacy of cinnamaldehyde and Echinacea purpurea plant extract in broilers against Eimeria acervulina.
PubMed:Effects of chemically characterized fractions from aerial parts of Echinacea purpurea and E. angustifolia on myelopoiesis in rats.
PubMed:Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.
PubMed:Effects of Echinaforce? treatment on ex vivo-stimulated blood cells.
PubMed:Dose-dependent in vivo effect of Rhodiola and Echinacea on the mitogen-induced lymphocyte proliferation in mice.
PubMed:Absolute/relative bioavailability and metabolism of dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (tetraenes) after intravenous and oral single doses to rats.
PubMed:Effects of phenytoin and Echinacea purpurea extract on proliferation and apoptosis of mouse embryonic palatal mesenchymal cells.
PubMed:A sensitive LC-MS/MS method for the quantitative analysis of the Echinacea purpurea constituent undeca-2-ene-8,10-diynoic acid isobutylamide in human plasma.
PubMed:Herb-drug interaction between Echinacea purpurea and darunavir-ritonavir in HIV-infected patients.
PubMed:Stimulatory effect of Echinacea purpurea extract on the trafficking activity of mouse dendritic cells: revealed by genomic and proteomic analyses.
PubMed:The effect of polyphenolic-polysaccharide conjugates from selected medicinal plants of Asteraceae family on the peroxynitrite-induced changes in blood platelet proteins.
PubMed:The potential use of Echinacea in acne: control of Propionibacterium acnes growth and inflammation.
PubMed:Establishment of recombinant cannabinoid receptor assays and characterization of several natural and synthetic ligands.
PubMed:Skin improvement and stability of Echinacea purpurea dermatological formulations.
PubMed:Echinacea purpurea aerial extract alters course of influenza infection in mice.
PubMed:The effect of standardized Echinacea purpurea extract on rat cytochrome P450 expression level.
PubMed:Carbon nanotube reinforced hollow fiber solid/liquid phase microextraction: a novel extraction technique for the measurement of caffeic acid in Echinacea purpurea herbal extracts combined with high-performance liquid chromatography.
PubMed:Echinacea purpurea extracts modulate murine dendritic cell fate and function.
PubMed:Bactericidal and anti-inflammatory properties of a standardized Echinacea extract (Echinaforce): dual actions against respiratory bacteria.
PubMed:Anti-viral properties and mode of action of standardized Echinacea purpurea extract against highly pathogenic avian influenza virus (H5N1, H7N7) and swine-origin H1N1 (S-OIV).
PubMed:Endogenous levels of Echinacea alkylamides and ketones are important contributors to the inhibition of prostaglandin E2 and nitric oxide production in cultured macrophages.
PubMed:Characterization and immunolocalization of arabinogalactan-proteins in roots of Echinacea purpurea.
PubMed:Activation of PPARgamma by metabolites from the flowers of purple coneflower (Echinacea purpurea).
PubMed:Comparison of alkylamide yield in ethanolic extracts prepared from fresh versus dry Echinacea purpurea utilizing HPLC-ESI-MS.
PubMed:The effect of Echinacea purpurea (L.) Moench extract on experimental prostate hyperplasia.
PubMed:Acetylcholinesterase inhibitory and antioxidant properties of Cyclotrichium niveum, Thymus praecox subsp. caucasicus var. caucasicus, Echinacea purpurea and E. pallida.
PubMed:Echinacea increases arginase activity and has anti-inflammatory properties in RAW 264.7 macrophage cells, indicative of alternative macrophage activation.
PubMed:Echinacea purpurea and osteopathic manipulative treatment in children with recurrent otitis media: a randomized controlled trial.
PubMed:Pharmacokinetics and immunomodulatory effects of phytotherapeutic lozenges (bonbons) with Echinacea purpurea extract.
PubMed:Effect of Echinacea purpurea (Asteraceae) aqueous extract on antibody response to Bothrops asper venom and immune cell response.
PubMed:P-Glycoprotein inhibitory activity of lipophilic constituents of Echinacea pallida roots in a human proximal tubular cell line.
PubMed:Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea.
PubMed:Echinacea purpurea L. in children: safety, tolerability, compliance, and clinical effectiveness in upper respiratory tract infections.
PubMed:Phytotherapeutic effects of Echinacea purpurea in gamma-irradiated mice.
PubMed:The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.
PubMed:Echinacea alkylamides modulate induced immune responses in T-cells.
PubMed:Effects of herbal products and their constituents on human cytochrome P450(2E1) activity.
PubMed:Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content.
PubMed:Influence of Echinacea purpurea (L.) Moench extract on the toxicity of cadmium.
PubMed:Assessment of the effect of Echinacea purpurea (L.) Moench on apoptotic and mitotic activity of liver cells during intoxication by cadmium.
PubMed:Effects of plant extracts on antioxidant status and oxidant-induced stress in Caco-2 cells.
PubMed:Oral Echinacea purpurea extract in low-grade, steroid-dependent, autoimmune idiopathic uveitis: a pilot study.
PubMed:Open, multicenter study to evaluate the tolerability and efficacy of Echinaforce Forte tablets in athletes.
PubMed:Liver enzyme-mediated oxidation of Echinacea purpurea alkylamides: production of novel metabolites and changes in immunomodulatory activity.
PubMed:Cytotoxic effects of Echinacea root hexanic extracts on human cancer cell lines.
PubMed:A comparison study of effects of Echinacea extract and levamisole on phenytoin-induced cleft palate in mice.
PubMed:Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells.
PubMed:Echinacea alkylamides inhibit interleukin-2 production by Jurkat T cells.
PubMed:[Composite tincture from the tops of the purple coneflower (Echinacea purpurea) and the fruits of the dog rose (Rosa canina): technology of production and evaluation of quality].
PubMed:Synergistic antioxidative effects of alkamides, caffeic acid derivatives, and polysaccharide fractions from Echinacea purpurea on in vitro oxidation of human low-density lipoproteins.
PubMed:Effect on prolactin secretion of Echinacea purpurea, hypericum perforatum and Eleutherococcus senticosus.
PubMed:A proprietary extract from the echinacea plant (Echinacea purpurea) enhances systemic immune response during a common cold.
PubMed:[Technology of extract improving the immune system].
PubMed:Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections.
PubMed:Enhancement of natural killer cells and increased survival of aging mice fed daily Echinacea root extract from youth.
PubMed:Analysis of the inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on the metabolic activity of cytochrome P450 3A4, 2D6, and 2C9.
PubMed:The effect of Echinacea purpurea extract on sexual glands of male rats.
PubMed:Complementary and alternative interventions in asthma, allergy, and immunology.
PubMed:Cytokine production by non-adherent mouse splenocyte cultures to Echinacea extracts.
PubMed:Comparative controlled study of Andrographis paniculata fixed combination, Kan Jang and an Echinacea preparation as adjuvant, in the treatment of uncomplicated respiratory disease in children.
PubMed:Enhancement of the humoral immune response by Echinacea purpurea in female Swiss mice.
PubMed:Trace elements analysis of Echinacea purpurea--herbal medicinal.
PubMed:[Technology and analysis of "Askoeziuofito" tablets].
PubMed:HPLC method validated for the simultaneous analysis of cichoric acid and alkamides in Echinacea purpurea plants and products.
PubMed:The effect of herbal remedy on the development of Trichinella spiralis infection in mice.
PubMed:Echinacea purpurea stimulates cellular immunity and anti-bacterial defence independently of the strain of mice.
PubMed:Effect of Echinacea (Echinacea Purpurea L. Moench) preparations on experimental prostate gland.
PubMed:Echinacea.
PubMed:Antiviral activity of characterized extracts from echinacea spp. (Heliantheae: Asteraceae) against herpes simplex virus (HSV-I).
PubMed:Evaluation of commercial ginkgo and echinacea dietary supplements for colchicine using liquid chromatography-tandem mass spectrometry.
PubMed:Immunological studies of Revitonil, a phytopharmaceutical containing Echinacea purpurea and Glycyrrhiza glabra root extract.
PubMed:Stabilization of caffeic acid derivatives in Echinacea purpurea L. glycerin extract.
PubMed:Effect of temperature on stability of marker constituents in Echinacea purpurea root formulations.
PubMed:The effect of immunization with killed tumor cells, with/without feeding of Echinacea purpurea in an erythroleukemic mouse model.
PubMed:Alkylamides of Echinacea purpurea stimulate alveolar macrophage function in normal rats.
PubMed:Anti-inflammatory and cicatrizing activity of Echinacea pallida Nutt. root extract.
PubMed:Synthesis of the alpha-L-Araf-(1-->2)-beta-D-Galp-(1-->6)-beta-D-Galp-(1-->6)-[alpha-L-Araf-(1-->2)]-beta-D-Galp-(1-->6)-D-Gal hexasaccharide as a possible repeating unit of the cell-cultured exudates of Echinacea purpurea arabinogalactan.
PubMed:Echinacea purpurea and melatonin augment natural-killer cells in leukemic mice and prolong life span.
PubMed:Effects of oral administration of Echinacea purpurea (American herb) on incidence of spontaneous leukemia caused by recombinant leukemia viruses in AKR/J mice.
PubMed:Does the extract of the plant Echinacea purpurea influence the clinical course of recurrent genital herpes?
PubMed:Scope and limitation of the application of the (methoxydimethyl)methyl group in the synthesis of 2'-O-, 6'-O- and 2',6'-di-O-(alpha-L-arabinofuranosyl)-beta-D-galactopyranosyl- (1-->6)-D-galactoses.
PubMed:[Extract of the Echinacea purpurea herb: an allopathic phytoimmunostimulant].
PubMed:A randomized controlled trial of the effect of fluid extract of Echinacea purpurea on the incidence and severity of colds and respiratory infections.
PubMed:Echinaforce and other Echinacea fresh plant preparations in the treatment of the common cold. A randomized, placebo controlled, double-blind clinical trial.
PubMed:Echinacea root extracts for the prevention of upper respiratory tract infections: a double-blind, placebo-controlled randomized trial.
PubMed:Antiviral activity of Viracea against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus.
PubMed:In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients.
PubMed:Benefit-risk assessment of the squeezed sap of the purple coneflower (Echinacea purpurea) for long-term oral immunostimulation.
PubMed:[The effects of plant preparations on cellular functions in body defense].
PubMed:[The effect of Echinacea angustifolia on non-specific cellular immunity in the mouse].
PubMed:[The effect of Echinacea purpurea Moench on phagocytosis in granulocytes measured by chemiluminescence].
PubMed:[Effect of a plant immunostimulant on phagocytosis of erythrocytes by the reticulohistiocytary system of isolated perfused rat liver].
PubMed:[Experimental tests of a plant extract from Echinacea purpurea Moench as a nonspecific stimulant. With special reference to the effects on the adrenal cortex].
PubMed:[Experimental studies on a plant extract from Echinacea purpurea Moench as a nonspecific irritant. With special reference to the effect on the adrenal cortex].
 
Notes:
a genus of perennial herbs used topically and internally. it contains echinacoside, glycosides; inulin; isobutyl amides, resin, and sesquiterpenes.
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