EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

niacinamide
3-pyridinecarboxamide

Supplier Sponsors

Name:pyridine-3-carboxamide
CAS Number: 98-92-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:202-713-4
FDA UNII:25X51I8RD4
Nikkaji Web:J3.988H
Beilstein Number:0383619
MDL:MFCD00006395
XlogP3:-0.40 (est)
Molecular Weight:122.12702000
Formula:C6 H6 N2 O
BioActivity Summary:listing
NMR Predictor:Predict (works with chrome or firefox)
Category:nutrient supplements
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
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US Patents:Search
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Pubchem Patents:Search
PubMed:Search
NCBI:Search
 FDA/DG SANTE Petitions, Reviews, Notices:
184.1535 Niacinamide (nicotinamide) View - review
FDA Mainterm (SATF):98-92-0 ; NIACINAMIDE
FDA Regulation:
FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.260 Enriched corn meals.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.305 Enriched farina.


FDA PART 137 -- CEREAL FLOURS AND RELATED PRODUCTS
Subpart B--Requirements for Specific Standardized Cereal Flours and Related Products
Sec. 137.350 Enriched rice.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.115 Enriched macaroni products.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.117 Enriched macaroni products with fortified protein.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.122 Enriched nonfat milk macaroni products.


FDA PART 139 -- MACARONI AND NOODLE PRODUCTS
Subpart B--Requirements for Specific Standardized Macaroni and Noodle Products
Sec. 139.155 Enriched noodle products.


FDA PART 184 -- DIRECT FOOD SUBSTANCES AFFIRMED AS GENERALLY RECOGNIZED AS SAFE
Subpart B--Listing of Specific Substances Affirmed as GRAS
Sec. 184.1535 Niacinamide.
 
Physical Properties:
Appearance:white crystalline powder (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 130.00 to 132.00 °C. @ 760.00 mm Hg
Boiling Point: 334.41 °C. @ 760.00 mm Hg (est)
Flash Point: 313.00 °F. TCC ( 156.00 °C. ) (est)
logP (o/w): -0.370
Soluble in:
 water, 500000 mg/L @ 25 °C (exp)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: smoothing agents
 
Suppliers:
Aceto
Niacinamide USP
AIDP
Niacinamide B3
American International Chemical, LLC.
Niacinamide
Atlantic Chemicals
Nicotinamide (Vitamin B3)
BOC Sciences
For experimental / research use only.
Nicotinamide >98%
Odor: characteristic
Use: Nicotinamide, a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an activator of sirtuins.
Charkit Chemical
NIACINAMIDE DC
Charkit Chemical
NIACINAMIDE USP GRANULAR
Charkit Chemical
NIACINAMIDE USP POWDER
Farbest-Tallman Foods
Niacinamide USP Granular
Flavor: characteristic
It is used in dietary supplement applications including tablets and hard shell capsules as a source of Vitamin B3.
Farbest-Tallman Foods
Niacinamide USP Powder
Flavor: characteristic
It is used in food, beverage and dietary supplement applications including bakery mixes, cereals, nutrition bars, nutrition powders and hard shell capsules as a source of Vitamin B3.
George Uhe Company
Niacinamide
Glentham Life Sciences
Nicotinamide
Graham Chemical
Vitamin B3
Penta International
NIACINAMIDE (Vitamin B3) FCC
Penta International
NIACINAMIDE (Vitamin B3) USP
Penta International
NIACINAMIDE (Vitamin B3)
Prinova
Niacinamide
Qingdao Dacon Trading
Niacinamide
Shiva Chemicals and Pharmaceuticals
Niacinamide
Sigma-Aldrich
For experimental / research use only.
Niacinamide ≥98.5% (HPLC)
Spec-Chem Industry
SpecWhite ® VB3
Tianjin Talent Chemical
VB3 (Nicotinamide)
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-rat LD50 3500 mg/kg
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 1390, 1986.

unreported-mammal (species unspecified) LD50 2500 mg/kg
Pharmaceutical Chemistry Journal Vol. 20, Pg. 29, 1986.

intraperitoneal-mouse LD50 2050 mg/kg
Radiation Research. Vol. 109, Pg. 479, 1987.

oral-mouse LD50 2500 mg/kg
Drugs in Japan Vol. 6, Pg. 545, 1982.

Dermal Toxicity:
subcutaneous-rat LD50 1680 mg/kg
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Proceedings of the Society for Experimental Biology and Medicine. Vol. 62, Pg. 19, 1946.

subcutaneous-mouse LD50 2000 mg/kg
Quarterly Journal of Pharmacy & Pharmacology. Vol. 19, Pg. 48, 1946.

Inhalation Toxicity:
Not determined
 
Safety in Use Information:
Category:
nutrient supplements
Recommendation for niacinamide usage levels up to:
 not for fragrance use.
 
Recommendation for niacinamide flavor usage levels up to:
 not for flavor use.
 
Safety References:
European Food Safety Authority (EFSA) reference(s):

Scientific Opinion on Dietary Reference Values for niacin
View page or View pdf

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for niacin
View page or View pdf

Niacin and contribution to normal energy-yielding metabolism: evaluation of a health claim pursuant to Article 14 of Regulation (EC) No 1924/2006
View page or View pdf

EPI System: View
ClinicalTrials.gov:search
Daily Med:search
NIOSH International Chemical Safety Cards:search
Chemical Carcinogenesis Research Information System:Search
AIDS Citations:Search
Cancer Citations:Search
Toxicology Citations:Search
Carcinogenic Potency Database:Search
EPA GENetic TOXicology:Search
EPA Substance Registry Services (TSCA):98-92-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :936
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
pyridine-3-carboxamide
Chemidplus:0000098920
EPA/NOAA CAMEO:hazardous materials
RTECS:98-92-0
 
References:
 pyridine-3-carboxamide
NIST Chemistry WebBook:Search Inchi
Canada Domestic Sub. List:98-92-0
Pubchem (cid):936
Pubchem (sid):134971470
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
FDA Substances Added to Food (formerly EAFUS):View
CHEBI:View
CHEMBL:View
Golm Metabolome Database:Search
Metabolomics Database:Search
KEGG (GenomeNet):C00153
HMDB (The Human Metabolome Database):HMDB01406
FooDB:FDB012485
YMDB (Yeast Metabolome Database):YMDB00274
Export Tariff Code:2936.29.1530
FDA Listing of Food Additive Status:View
VCF-Online:VCF Volatile Compounds in Food
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
•oral: tablets: 50 mg; 100 mg; 500 mg. (available by nonproprietary name). •nicotinamide is sold in three grades: pharmaceutical (usp, nf, ph. eur.(european pharmacopeia)), food (uspfcc), and feed-technical.
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 cacao bean
Search Trop Picture
 fenugreek seed
Search Trop Picture
 flax seed
Search Trop Picture
 not found in nature
 parsley plant
Search Trop Picture
 pea sprout
Search Trop Picture
 saffron
Search Trop Picture
 sage plant
Search Trop Picture
 
Synonyms:
m-(aminocarbonyl)pyridine
meta-(aminocarbonyl)pyridine
3-carbamoylpyridine
 niacinamide B3
 niacinamide free flow powder
 niacinamide USP
 niacinamide USP granular
 niacinamide USP powder
 nicotinamide
 nicotinamide (vitamin B3)
 nicotinic amide
 pyridine-3-carboxamide
 pyridine-3-carboxylic acid amide
3-pyridinecarboxamide
beta-pyridinecarboxamide
 vitamin B3
 

Articles:

PubMed:Sorafenib and triptolide as combination therapy for hepatocellular carcinoma.
J-Stage:Increased Conversion of Tryptophan to Nicotinamide in Rats by Dietary Valproate
PubMed:Effect of two anti-fungal treatments (metrafenone and boscalid plus kresoxim-methyl) applied to vines on the color and phenol profile of different red wines.
PubMed:Advances in managing hepatocellular carcinoma.
PubMed:A preclinical evaluation of a novel multikinase inhibitor, SKLB-329, as a therapeutic agent against hepatocellular carcinoma.
PubMed:Anti-angiogenesis in prostate cancer: knocked down but not out.
PubMed:Sorafenib in metastatic thyroid cancer: a systematic review.
PubMed:Effects of irrigation levels on interactions among Lygus hesperus (Hemiptera: Miridae), insecticides, and predators in cotton.
PubMed:Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract.
PubMed:The effects of glycine, L-threonine, and L-cystine supplementation to a 9% casein diet on the conversions of L-tryptophan to nicotinamide and to serotonin in rats.
PubMed:Pantothenic acid deficiency may increase the urinary excretion of 2-oxo acids and nicotinamide catabolites in rats.
PubMed:Behavior of pyrimethanil, pyraclostrobin, boscalid, cypermethrin and chlorpyrifos residues on raspberry fruit and leaves of Laszka variety.
PubMed:Development and validation of an HPLC-UV method for sorafenib quantification in human plasma and application to patients with cancer in routine clinical practice.
PubMed:Hydrosoluble vitamins.
PubMed:Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.
PubMed:Oral and systemic photoprotection.
PubMed:Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.
PubMed:Pentamethylquercetin reduces fat deposition via Sirt1-mediated pathways in male obese mice induced by a high fat diet.
PubMed:Effect of concomitant administration of L-glutamine and cycloart-23-ene-3β, 25-diol (B2) with sitagliptin in GLP-1 (7-36) amide secretion, biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague Dawley rats.
PubMed:Lactobacillus acidophilus La5 and Bifidobacterium lactis Bb12 induce different age-related metabolic profiles revealed by 1H-NMR spectroscopy in urine and feces of mice.
PubMed:Assessment of nutritional status in cancer--the relationship between body composition and pharmacokinetics.
PubMed:Effect of pH(24h), curing salts and muscle types on the oxidative stability, free amino acids profile and vitamin B2, B3 and B6 content of dry-cured ham.
PubMed:Impact of dementia progression on food-related processes: a qualitative study of caregivers' perspectives.
PubMed:Body composition in chemotherapy: the promising role of CT scans.
PubMed:Alternative formulations of sorafenib for use in children.
PubMed:Dietary flaxseed oil and fish oil modulates expression of antioxidant and inflammatory genes with alleviation of protein glycation status and inflammation in liver of streptozotocin-nicotinamide induced diabetic rats.
PubMed:The niacin required for optimum growth can be synthesized from L-tryptophan in growing mice lacking tryptophan-2,3-dioxygenase.
PubMed:Supplementing healthy women with up to 5.0 g/d of L-tryptophan has no adverse effects.
PubMed:Amelioration by chicory seed extract of diabetes- and oleic acid-induced non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) via modulation of PPARα and SREBP-1.
PubMed:Oral L-glutamine increases active GLP-1 (7-36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats.
PubMed:Flour fortification in South Africa: post-implementation survey of micronutrient levels at point of retail.
PubMed:A novel role of cytosolic protein synthesis inhibition in aminoglycoside ototoxicity.
PubMed:Increased conversion of tryptophan to nicotinamide in rats by dietary valproate.
PubMed:Method development and validation for boscalid in blueberries by solid-phase microextraction gas chromatography, and their degradation kinetics.
PubMed:Cycloart-23-ene-3β, 25-diol stimulates GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats: a mechanistic approach.
PubMed:Establishment of true niacin deficiency in quinolinic acid phosphoribosyltransferase knockout mice.
PubMed:The metabolites in the tryptophan degradation pathway might be useful to determine the tolerable upper intake level of tryptophan intake in rats.
PubMed:Nicotinamide induces male-specific body weight loss in the postnatal period through molecular regulation of the hypothalamus and liver.
PubMed:The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats.
PubMed:The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats.
PubMed:[Relationship between sorafenib-associated hand-food skin reaction and efficacy in treatment of advanced hepatocellular carcinoma].
PubMed:Life beyond kinases: structure-based discovery of sorafenib as nanomolar antagonist of 5-HT receptors.
PubMed:[Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on iron metabolic homeostasis].
PubMed:Meta-analysis of randomized controlled trials for the incidence and risk of treatment-related mortality in patients with cancer treated with vascular endothelial growth factor tyrosine kinase inhibitors.
PubMed:The urinary excretory ratio of nicotinamide catabolites was associated with the conversion ratio of tryptophan to nicotinamide in growing rats fed a niacin-free 20% casein diet.
PubMed:[Renal tolerance of targeted therapies].
PubMed:A new rapid and sensitive LC-MS assay for the determination of sorafenib in plasma: application to a patient undergoing hemodialysis.
PubMed:Genotype and environment effects on the contents of vitamins B1, B2, B3, and B6 in wheat grain.
PubMed:Simultaneous determination of flonicamid and its metabolites in vegetables using QuEChERS and reverse-phase liquid chromatography-tandem mass spectrometry.
PubMed:Resveratrol prevents norepinephrine induced hypertrophy in adult rat cardiomyocytes, by activating NO-AMPK pathway.
PubMed:Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells.
PubMed:Physico-mechanical and stability evaluation of carbamazepine cocrystal with nicotinamide.
PubMed:Fate of iprovalicarb, indoxacarb, and boscalid residues in grapes and wine by GC-ITMS analysis.
PubMed:What is the indication for sorafenib in hepatocellular carcinoma? A clinical challenge.
PubMed:Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats.
PubMed:Study to evaluate the impact of heat treatment on water soluble vitamins in milk.
PubMed:Sorafenib: activity and clinical application in patients with hepatocellular carcinoma.
PubMed:Activation of phosphatidylinositol 3-kinase/Akt signaling pathway mediates acquired resistance to sorafenib in hepatocellular carcinoma cells.
PubMed:Formulation of controlled-release capsules of biopharmaceutical classification system I drugs using niacin as a model.
PubMed:Antidiabetic potential of α-amylase inhibitor from the seeds of Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic mice.
PubMed:A novel coenzyme A:diacylglycerol acyltransferase 1 inhibitor stimulates lipid metabolism in muscle and lowers weight in animal models of obesity.
PubMed:Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice.
PubMed:[Treatment of primary hepatocellular carcinoma].
PubMed:18[F]FDG small animal PET study of sorafenib efficacy in lymphoma preclinical models.
PubMed:Improving the stability of probiotic bacteria in model fruit juices using vitamins and antioxidants.
PubMed:Effect of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on infectious morbidity of preschool children.
PubMed:Sorafenib: a clinical and pharmacologic review.
PubMed:Minor crops for export: a case study of boscalid, pyraclostrobin, lufenuron and lambda-cyhalothrin residue levels on green beans and spring onions in Egypt.
PubMed:Sorafenib, a multikinase inhibitor, enhances the response of melanoma to regional chemotherapy.
PubMed:Chronic niacin overload may be involved in the increased prevalence of obesity in US children.
PubMed:Injection order effects on efficacy of calcium chloride and sodium tripolyphosphate in controlling the pink color defect in uncured, intact turkey breast.
PubMed:New therapeutic strategies for renal cell carcinoma.
PubMed:[Use of sorafenib in patients with hepatocellular or renal carcinoma].
PubMed:[Chronic nicotinamide overload and type 2 diabetes].
PubMed:Synthesis of nicotinamide-based molecularly imprinted microspheres and in vitro controlled release studies.
PubMed:Antidiabetic activity of cycloart-23-ene-3beta, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice.
PubMed:Frequent dose interruptions are required for patients receiving oral kinase inhibitor therapy for advanced renal cell carcinoma.
PubMed:Consideration of diurnal variations in human blood NAD and NADP concentrations.
PubMed:Investigation of niacin on parameters of metabolism in a physiologic dose: randomized, double-blind clinical trial with three different dosages.
PubMed:Response to sorafenib after sunitinib-induced acute heart failure in a patient with metastatic renal cell carcinoma: case report and review of the literature.
PubMed:Comparison of the nicotinamide catabolism among rat strains.
PubMed:Effects of vitamin A, vitamin A plus iron and multiple micronutrient-fortified seasoning powder on preschool children in a suburb of Chongqing, China.
PubMed:Commentary: Sorafenib -- the end of a long journey in search of systemic therapy for hepatocellular carcinoma, or the beginning?
PubMed:Sorafenib for the treatment of unresectable hepatocellular carcinoma.
PubMed:Quantitative investigation of trigonelline, nicotinic acid, and nicotinamide in foods, urine, and plasma by means of LC-MS/MS and stable isotope dilution analysis.
PubMed:Age-related alterations of B-group vitamin contents in urine, blood and liver from rats.
PubMed:Maternal intake of fat, riboflavin and nicotinamide and the risk of having offspring with congenital heart defects.
PubMed:The formation of nicotinamide by administration of di(2-ethylhexyl)phthalate does not cause growth retardation in young rats in contrast with excess exogenous administration of nicotinamide.
PubMed:Sulphurous mineral water oral therapy: effects on erythrocyte metabolism.
PubMed:Targeted therapy in renal cell carcinoma.
PubMed:Targeted therapy in advanced non-small-cell lung cancer.
PubMed:Structure analysis of aromatic medicines containing nitrogen using near-infrared spectroscopy and generalized two-dimensional correlation spectroscopy.
PubMed:Mcl-1: a gateway to TRAIL sensitization.
PubMed:New therapeutic directions for advanced pancreatic cancer: targeting the epidermal growth factor and vascular endothelial growth factor pathways.
PubMed:Chemotherapeutic agents and the skin: An update.
PubMed:Effect of nicotinamide administration on the tryptophan-nicotinamide pathway in humans.
PubMed:FDA approves sorafenib for patients with inoperable liver cancer.
PubMed:Adipose tissue failure and mitochondria as a possible target for improvement by bioactive food components.
PubMed:Changes in vitamin status of Indian Antarctic expeditioners during a one-month stay in Austral Summer.
PubMed:Sunitinib, sorafenib and mTOR inhibitors in renal cancer.
PubMed:Sorafenib: a promising new targeted therapy for renal cell carcinoma.
PubMed:Protein kinase inhibitors in the treatment of renal cell carcinoma: sorafenib.
PubMed:Analysis of flonicamid and its metabolites in dried hops by liquid chromatography-tandem mass spectrometry.
PubMed:[Vitamin intake in an average diet of Warsaw adult inhabitants].
PubMed:Sorafenib and sunitinib: novel targeted therapies for renal cell cancer.
PubMed:The effect of recent drug approvals on translational research and drug development.
PubMed:Simultaneous determination of B-group vitamins in enriched Brazilian dairy products.
PubMed:Niacin nutritional status in HIV type 1-positive children: preliminary data.
PubMed:Nongenetic model of type 2 diabetes: a comparative study.
PubMed:Sunitinib malate and sorafenib may be beneficial at the treatment of advanced bladder cancer due to their anti-angiogenic effects.
PubMed:Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha.
PubMed:Sorafenib and sunitinib in the treatment of advanced non-small cell lung cancer.
PubMed:Effective palliation of advanced cholangiocarcinoma with sorafenib: a two-patient case report.
PubMed:Rhizopus oligosporus and yeast co-cultivation during barley tempeh fermentation--nutritional impact and real-time PCR quantification of fungal growth dynamics.
PubMed:Sorafenib for the treatment of advanced renal cell carcinoma.
PubMed:Targeted therapy for metastatic renal cell carcinoma.
PubMed:Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast.
PubMed:Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin.
PubMed:Pharmacy benefit spending on oral chemotherapy drugs.
PubMed:Simultaneous determination of riboflavin, pyridoxine, nicotinamide, caffeine and taurine in energy drinks by planar chromatography-multiple detection with confirmation by electrospray ionization mass spectrometry.
PubMed:Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH.
PubMed:Sorafenib: recent update on activity as a single agent and in combination with interferon-alpha2 in patients with advanced-stage renal cell carcinoma.
PubMed:Tryptophan-niacin metabolism in rat with puromycin aminonucleoside-induced nephrosis.
PubMed:Treatment for advanced kidney cancer.
PubMed:Development of a gas-liquid chromatographic method for the analysis of fatty acid tryptamides in cocoa products.
PubMed:Final report of the safety assessment of niacinamide and niacin.
PubMed:Effects of excess pantothenic acid administration on the other water-soluble vitamin metabolisms in rats.
PubMed:Drug approval triggers debate on future direction for cancer treatments.
PubMed:Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment.
PubMed:Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats.
PubMed:Update on angiogenesis inhibitors.
PubMed:Nicotinamide in relation to dietary nicotinic acid and nine other vitamins and larval development of Ceratitis capitata (Diptera: Tephritidae).
PubMed:Water-soluble vitamins: research update.
PubMed:Cancer. Encouraging results for second-generation antiangiogenesis drugs.
PubMed:Changes in the urinary excretion of the metabolites of the tryptophan-niacin pathway during pregnancy in Japanese women and rats.
PubMed:Conversion ratio of tryptophan to niacin in Japanese women fed a purified diet conforming to the Japanese Dietary Reference Intakes.
PubMed:The role of antioxidant micronutrients in the prevention of diabetic complications.
PubMed:[Action site of bisphenol A as metabolic disruptor lies in the tryptophan-nicotinamide conversion pathway].
PubMed:Niacin metabolite excretion in alcoholic pellagra and AIDS patients with and without diarrhea.
PubMed:[Metabolic disturbance of tryptophan-nicotinamide conversion pathway by putative endocrine disruptors, bisphenol A and styrene monomer].
PubMed:The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin.
PubMed:Effects of excess nicotinamide administration on the urinary excretion of nicotinamide N-oxide and nicotinuric acid by rats.
PubMed:A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting.
PubMed:Clinical trials. Diabetes' brave new world.
PubMed:[Changes in vitamins intake in overweight and obese adults after low-energy diets].
PubMed:Diurnal variations in human urinary excretion of nicotinamide catabolites: effects of stress on the metabolism of nicotinamide.
PubMed:BAY 43-9006: early clinical data in patients with advanced solid malignancies.
PubMed:Rapid determination of thiamine, riboflavin, pyridoxine, and niacinamide in infant formulas by liquid chromatography.
PubMed:How to re-energise old mitochondria without shooting yourself in the foot.
PubMed:Mild streptozotocin diabetes in the G?ttingen minipig. A novel model of moderate insulin deficiency and diabetes.
PubMed:Prevention of cyclophosphamide-induced accelerated diabetes in the NOD mouse by nicotinamide or a soy protein-based infant formula.
PubMed:[Characteristics of actual nutrition and health of children in regions of the Russian Federation].
PubMed:Determination of niacin in infant formula by solid-phase extraction and anion-exchange liquid chromatography.
PubMed:[Contents of water-soluble vitamins in canned fish and seafood].
PubMed:Safety of high-dose nicotinamide: a review.
PubMed:Simultaneous determination of nicotinic acid and nicotinamide in cooked sausages.
PubMed:IDDM prevention trials in progress--a critical assessment.
PubMed:Increased conversion ratio of tryptophan to niacin in severe food restriction.
PubMed:Micronutrients as nutriceutical interventions in diabetes mellitus.
PubMed:Inhibition of pink color development in cooked, uncured ground turkey through the binding of non-pink generating ligands to muscle pigments.
PubMed:Development of a HPLC method for the simultaneous determination of several B-vitamins and ascorbic acid.
PubMed:Decreases in aggression in tryptophan-supplemented broiler breeder males are not due to increases in blood niacin levels.
PubMed:Relative activity of N-(beta-D-glucopyranosyl)nicotinic acid to nicotinic acid as a niacin nutrient in rats and in Lactobacillus plantarum ATCC 8014.
PubMed:Preparation of controlled release granules of TA-5707F using enteric polymers and ethylcellulose, and their in vivo evaluation.
PubMed:Nicotinamide pharmacokinetics in normal volunteers and patients undergoing palliative radiotherapy.
PubMed:In vitro/in vivo evaluation of two series of TA-5707F controlled release matrix tablets prepared with hydroxypropyl methyl cellulose derivatives with entero-soluble or gel-formation properties.
PubMed:Dietary nicotinamide supplementation increases xanthine oxidoreductase activity in the kidney and heart but not liver of obese Zucker rats.
PubMed:Nicotinamide megadosing increases hepatic poly(ADP-ribose) levels in choline-deficient rats.
PubMed:Preparation of controlled release tablets of TA-5707F with wax matrix type and their in vivo evaluation in beagle dogs.
PubMed:In vivo methylation capacity is not impaired in healthy men during short-term dietary folate and methyl group restriction.
PubMed:Large supplements of nicotinic acid and nicotinamide increase tissue NAD+ and poly(ADP-ribose) levels but do not affect diethylnitrosamine-induced altered hepatic foci in Fischer-344 rats.
PubMed:[B group vitamin metabolism in duodenal ulcer disease, hypertension, and ischemic heart disease].
PubMed:Kinetics of niacin supplements in lactating dairy cows.
PubMed:[Vitamin and mineral enrichment of wheat flour of the high and first class quality].
PubMed:[The effect of riboflavin supply on metabolism of water-soluble vitamins].
PubMed:Kinetic analysis of the loss of some B-vitamins during the cooking of macaroni.
PubMed:[Studies on the preparation of sample solution for determination of nicotinic acid and nicotinamide in foods by high performance liquid chromatography].
PubMed:Determination of nicotinamide and pyridoxine in an elemental diet by column-switching high-performance liquid chromatography with UV detection.
PubMed:Metabolic fate of nicotinamide in LEC rats.
PubMed:[Can type-1 diabetes in children be prevented?].
PubMed:Pharmacokinetic profile of nicorandil in humans: an overview.
PubMed:[Features of poly-ADP-ribosylation and chromatin structure under conditions of varying NAD content in the rat liver].
PubMed:Effect of dietary tryptophan levels on the urinary excretion of nicotinamide and its metabolites in rats fed a niacin-free diet or a constant total protein level.
PubMed:Niacin catabolism in rodents.
PubMed:[The effect of thiamine, riboflavin, nicotinamide and ascorbic acid on the formation of nitrosamines in meat products].
PubMed:Monitoring the voluntary fortification of maize meal with riboflavin and nicotinamide.
PubMed:Correlation between niacin equivalent intake and urinary excretion of its metabolites, N'-methylnicotinamide, N'-methyl-2-pyridone-5-carboxamide, and N'-methyl-4-pyridone-3-carboxamide, in humans consuming a self-selected food.
PubMed:Effect of supplementing low protein diets with the limiting amino acids on the excretion of N1-methylnicotinamide and its pyridones in rats.
PubMed:Fate of excess nicotinamide and nicotinic acid differs in rats.
PubMed:Purification procedure for the determination of niacin vitamers in gastrointestinal contents and blood.
PubMed:Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats.
PubMed:Simultaneous micro-determination of nicotinamide and its major metabolites, N1-methyl-2-pyridone-5-carboxamide and N1-methyl-4-pyridone-3-carboxamide, by high-performance liquid chromatography.
PubMed:High-performance liquid chromatographic determination of nicotinamide in rat tissue samples and blood after extraction with diethyl ether.
PubMed:Determination of nicotinamide in pre-mixes by near-infrared reflectance spectrometry.
PubMed:Muscle creatine content in rats given repeated large doses of nicotinamide: effects of dietary methionine, choline, carnitine, and other supplements.
PubMed:Bioavailability of niacin from processed groundnuts.
PubMed:On-line generation of cyanogen chloride in semiautomated determination of niacin and niacinamide in food products.
PubMed:Dietary influences on neurotransmission.
PubMed:[Evaluation of dietary vitamin intake in Burgundy (France)].
PubMed:The effects of increased levels of niacin supplementation on growth rate and carcass composition of broiler chickens.
PubMed:Pathology of 6-aminonicotinamide toxicosis in the rabbit.
PubMed:[An automated photometric method for determining niacin and niacinamide content in grain and cereals].
PubMed:N-nitrosodimethylamine carcinogenesis in nicotinamide-deficient rats.
PubMed:[Correction of avitaminosis in workers of beet sugar-processing plant].
PubMed:Niacinamide in canned tomato sauce.
PubMed:Evaluation of urea-acid system as medium of extraction for the B-group vitamins. Part II. Simplified semi-automated chemical analysis for niacin and niacinamide in cereal products.
PubMed:Metabolic effects of nicotinamide administration in rats.
PubMed:The available niacin values of foods for rats and their relation to analytical values.
PubMed:Niacin-tryptophan relationships for evaluating niacin equivalents.
PubMed:The effects of butylated hydroxyanisole and butylated hydroxytoluene on renal function in the rat. II. Effects on organic acid and base transport.
PubMed:The effects of dietary niacin and riboflavin on voluntary intake and metabolism of ethanol in rats.
PubMed:Semiautomated method for niacin and niacinamide in food products: collaborative study.
PubMed:Metabolic abnormalities of tryptophan and nicotinic acid in patients with rheumatoid arthritis.
PubMed:[Induction of tyrosine aminotransferase (EC 2.5.1.5) by nicotinamide in rat liver (author's transl)].
PubMed:The effect of hexose monophosphate shunt inhibitors on adenohypophyseal and ceruloplasmin reactions to oestrogen.
PubMed:[Niacin allowance of students of a sports college].
PubMed:The role of technology in modern nutrition.
PubMed:Automated method for the determination of niacin and niacinamide in cereal products: collaborative study.
PubMed:[Group B vitamins in some typical Italian cheese: Parmigiano-reggiano, Pecorino romano and Gorgonzola (author's transl)].
PubMed:Effect of enrichment of maize meal with nicotinic acid and riboflavin upon the vitamin and protein nutritional status of young school-going and pre-school children.
PubMed:The semiautomated determination of niacin and niacinamide in food products.
PubMed:Report on vitamins and other nutrients.
PubMed:Possible substitutes for nitrite for pigment formation in cured meat products.
PubMed:[Importance of prophylactic vitaminization of the food ration of persons working under emotional stress for normalizing changes in lipid metabolism].
PubMed:[Vitamins. 9. Niacin].
PubMed:Nutrition of the elderly living at home.
PubMed:Study of the vitamin C, B 1 , B 2 , B 6 , PP balance in men at the Mirny station in Antarctica.
PubMed:[Vitamin A, beta-carotene, and vitamin C analysis of diet in homes for the aged in various regions of Switzerland. B. Rural homes].
PubMed:Food selection studies of rats fed tryptophan-imbalanced diets with or without niacin.
PubMed:[Evaluation of the efficacy of long-term vitaminization of the food ration (effect on general morbidity)].
PubMed:The clinical and biochemical effects of riboflavin and nicotinamide supplementation upon Bantu school children using maize meal as carrier medium.
PubMed:[Nutritive value of "meals on wheels" distributed to the elderly. I. Normal diet].
PubMed:The assessment of dietary vitamin intake of 24 Istrian farmers. I. Laboratory analysis versus food tables.
PubMed:[Vitamins of barley, malt and beer].
PubMed:[Vitamins of cider].
PubMed:[Vitamins of wine].
PubMed:[Effect of ionizing radiation on group B and C vitamin content of various foods].
PubMed:[Level of tryptophan and vitamin PP in vegetable food products of intertropical Africa].
PubMed:Assessment of automated nitrogen analysis of biological fluids with reference to the Kjeldahl method.
PubMed:[Changes in some indices of the food value of meat during heating by ultrahigh frequency waves].
PubMed:[Changes in the nutrition of single women after the age of 70].
 
Notes:
an important compound functioning as a component of the coenzyme nad. its primary significance is in the prevention and/or cure of blacktongue and pellagra. most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. Widespread in plants, e.g. rice, yeast and fungi. Dietary supplement, may be used in infant formulas Nicotinamide, also known as niacinamide and nicotinic acid amide, is the amide of nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is part of the vitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and, though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacologic and toxic effects of niacin, which occur incidental to niacin's conversion. (Wikipedia)
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