EU/US Properties Organoleptics Cosmetics Suppliers Safety Safety in use Safety references References Other Blenders Uses Occurrence Synonyms Articles Notes
 

hydrofluorocarbon 227EA
propane, 1,1,1,2,3,3,3-heptafluoro-

Supplier Sponsors

Name:1,1,1,2,3,3,3-heptafluoropropane
CAS Number: 431-89-0Picture of molecule3D/inchi
ECHA EINECS - REACH Pre-Reg:207-079-2
FDA UNII:R40P36GDK6
Nikkaji Web:J28.278B
XlogP3-AA:2.90 (est)
Molecular Weight:170.02979240
Formula:C3 H F7
NMR Predictor:Predict (works with chrome or firefox)
Category:propellants, aerating agents, and gas
 
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Google Scholar:Search
Google Books:Search
Google Scholar: with word "volatile"Search
Google Scholar: with word "flavor"Search
Google Scholar: with word "odor"Search
Google Patents:Search
US Patents:Search
EU Patents:Search
Pubchem Patents:Search
PubMed:Search
NCBI:Search
 
Physical Properties:
Appearance:colorless gas (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point:-131.00 °C. @ 760.00 mm Hg (est)
Boiling Point: -19.00 °C. @ 760.00 mm Hg (est)
Vapor Pressure:3402.334000 mmHg @ 25.00 °C. (est)
Vapor Density:4.2 at ( Air = 1 )
Flash Point: -58.00 °F. TCC ( -50.10 °C. ) (est)
logP (o/w): 1.610 (est)
Soluble in:
 water, 79.5 mg/L @ 25 °C (est)
 
Organoleptic Properties:
Odor and/or flavor descriptions from others (if found).
 
Cosmetic Information:
CosIng:cosmetic data
Cosmetic Uses: propellants
 
Suppliers:
BOC Sciences
For experimental / research use only.
1,1,1,2,3,3,3-Heptafluoropropane 95%
Matrix Scientific
For experimental / research use only.
2H-Heptafluoropropane, 98%
 
Safety Information:
 
Hazards identification
 
Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements
 
Pictogram
 
Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
Not determined
Dermal Toxicity:
Not determined
Inhalation Toxicity:
inhalation-mouse LC > 7200000 mg/m3/4H
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996.

inhalation-rat LC > 7200000 mg/m3/4H
BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Toksikologicheskii Vestnik. Vol. (3), Pg. 37, 1996.

 
Safety in Use Information:
Category:
propellants, aerating agents, and gas
Recommendation for hydrofluorocarbon 227EA usage levels up to:
 not for fragrance use.
 
Recommendation for hydrofluorocarbon 227EA flavor usage levels up to:
 not for flavor use.
 
Safety References:
EPI System: View
Chemical Carcinogenesis Research Information System:Search
Cancer Citations:Search
Toxicology Citations:Search
EPA Substance Registry Services (TSCA):431-89-0
EPA ACToR:Toxicology Data
EPA Substance Registry Services (SRS):Registry
Laboratory Chemical Safety Summary :67940
National Institute of Allergy and Infectious Diseases:Data
WGK Germany:1
1,1,1,2,3,3,3-heptafluoropropane
Chemidplus:0000431890
 
References:
 1,1,1,2,3,3,3-heptafluoropropane
NIST Chemistry WebBook:Search Inchi
Pubchem (cid):67940
Pubchem (sid):135150719
 
Other Information:
(IUPAC):Atomic Weights of the Elements 2011 (pdf)
Videos:The Periodic Table of Videos
tgsc:Atomic Weights use for this web site
(IUPAC):Periodic Table of the Elements
CHEMBL:View
KEGG (GenomeNet):D10216
HMDB (The Human Metabolome Database):Search
ChemSpider:View
Wikipedia:View
Formulations/Preparations:
solkane 227 pharma (solvay fluor)
 
Potential Blenders and core components note
None Found
 
Potential Uses:
None Found
 
Occurrence (nature, food, other):note
 not found in nature
 
Synonyms:
 apaflurane
 FM 200
1,1,1,2,3,3,3-heptafluoropropane
2H-heptafluoropropane
 HFA-227
 HFC 227
 HFC-227EA
2-hydroheptafluoropropane
2-hydroperfluoropropane
 khladon 227
 propane, 1,1,1,2,3,3,3-heptafluoro-
 solkane 227
 

Articles:

PubMed:Influence of Suspension Stabilisers on the Delivery of Protein-Loaded Porous Poly (DL-Lactide-co-Glycolide) (PLGA) Microparticles via Pressurised Metered Dose Inhaler (pMDI).
PubMed:Reverse aqueous emulsions and microemulsions in HFA227 propellant stabilized by non-ionic ethoxylated amphiphiles.
PubMed:Solvent-solute interactions in hydrofluoroalkane propellants.
PubMed:Biocompatible and biodegradable copolymer stabilizers for hydrofluoroalkane dispersions: a colloidal probe microscopy investigation.
PubMed:Characterization of fine particle and gaseous emissions during school bus idling.
PubMed:Determination of 1,1,1,2,3,3,3-heptafluoropropane (HFP) in blood by headspace gas chromatography-mass spectrometry.
PubMed:Influence of the size of micronized active pharmaceutical ingredient on the aerodynamic particle size and stability of a metered dose inhaler.
PubMed:Novel nanoparticles for pulmonary drug administration.
PubMed:Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3, 3-heptafluoropropane) following whole-body exposure.
PubMed:Setting safe acute exposure limits for halon replacement chemicals using physiologically based pharmacokinetic modeling.
PubMed:Surfactant dissolution and water solubilization in chlorine-free liquified gas propellants.
PubMed:Tolerability and in vivo performance of a novel freon-free metered dose inhaler for a fixed combinational product of reproterol and disodium cromoglycate.
PubMed:Biotransformation of the aerosol propellant 1,1,1,2,3,3,3-heptafluoropropane (HFA-227): lack of protein binding of the metabolite hexafluoroacetone.
 
Notes:
None found
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